A NEW study published in the
New England Journal of Medicine
has found that Botox
(onabotulinumtoxinA) may help
reduce the frequency of daily
episodes of urinary incontinence.
The six-month trial involved 249
women with idiopathic urgency
urinary incontinence who had five or
more episodes of urgency urinary
incontinence per three-day period.
Participants received either a
daily oral anticholinergic drug or
one intradetrusor injection of
100U of Botox.
The results found the mean
reduction in episodes of urgency
urinary incontinence per day was
3.4 in the anticholinergic group
and 3.3 in the Botox group.
Complete resolution of urgency
urinary incontinence was also
reported by 13% and 27% of the
women, respectively, whilst quality
of life improved in both groups,
without significant between-group
differences.
Interestingly, the anticholinergic
group had a higher rate of dry
mouth (46% vs. 31%) but lower
rates of catheter use at two
months (0% vs. 5%) and urinary
tract infections (13% vs. 33%).
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