A STUDY published in the Annals of Internal Medicine found small differences in weight change among patients starting one of eight first-line antidepressants in the US.
Researchers from Harvard Medical School and the Pilgrim Health Care Institute analysed electronic health records of over 183,000 adults.
Bupropion was consistently linked to the least weight gain.
At six months, users of escitalopram, paroxetine, and duloxetine gained 0.3 to 0.4 kg more and were 10-15% more likely to gain at least 5% of their baseline weight compared to sertraline users.
However, Bupropion users gained 0.22kg less and were 15% less likely to gain 5% of their baseline weight.
The researchers said these findings are crucial as concerns about weight gain can impact medication adherence.
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