Pharmacy Daily | Statin update alert

THE TGA has released a new Medicines Safety Update which includes a warning regarding the use of statins with macrolide antibiotics. According to the report the combined use of macrolide antibiotics and statins can increase the risk of myopathy and rhabdomyolysis, and it is suggested that if a statin patient is prescribed a macrolide, their prescriber should consider temporarily stopping the statin. Alternatively, it is suggested that the prescriber should consider choosing a different antibiotic. The Medicines Safety Update also includes a warning to ensure that correct insertion technique is used with the levonorgestrelreleasing intrauterine system (Mirena) to minimise the risk of uterine perforation. In addition the report states that the majority of adverse event reports involving rivaroxaban received by the TGA describe thrombotic or haemorrhagic events, consistent with its known safety profile.

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