MONASH researchers have announced that they have solved the first crystal structure of the A1 adenosine G protein-coupled receptor, an important therapeutic target for treating cardiac injury after a heart attack, memory disorders and chronic pain.
The study, published in the journal Cell, details atomic-level information of the A1 adenosine receptor protein and reveals that the physical shape of its hormone binding pocket (pictured) is very different from that of a related adenosine receptor, providing new clues about how drugs can be used to more selectivity target these proteins.
Lead researcher Professor Arthur Christopoulos says that this new discovery can improve our understanding of how allosteric modulators and receptors interact, and can lead to the design of more selective drugs with fewer side effects for a range of neurological, cardiovascular, pain and other diseases.
Visit cell.com for the abstract.
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