Pharmacy Daily | PPI warning change

THE European Medicines Agency has updated its warning on the interaction between the antiplatelet medication clopidogrel and a range of proton-pump inhibitors. The change comes after the agency reviewed recent data and found that there were no “solid grounds to extend the warning to PPIs other than omeprazole and esomeprazole”. The initial warning from the agency was issued in May last year, regarding the concomitant use of medicines containing clopidogrel (an antiplatelet for the prevention of blood clots) and PPIs (for the treatment of gastric reflux). The committee has amended its initial warning to only discourage the concomitant use of clopidogrel and omeprazole or esomeprazole with proton pump inhibitors. The EMEA is now recommending that the class warning for all PPIs with clopidogrel be replaced with a warning stating that only the concomitant use of clopidogrel and omeprazole or esomeprazole should be discouraged.

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