Codeine varied effect
June 27, 2016
About 8% of the population is
unable to metabolise codeine to
its active metabolite, morphine,
leading to a poor response
to codeine for these people,
according to a review article in The
Conversation by Olaf Drummer,
Professor of Forensic Medicine,
Monash University.
On the other hand, there are
around 5% of the population who
metabolise codeine to morphine
at a much larger extent placing
them at increased risk of toxicity,
Drummer writes.
The article also summarises
dosing issues, combination
products containing codeine, side
effects, adverse drug combinations
and people for who the drug is
contraindicated.
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