ACE and zinc reaction
January 15, 2013
ACE inhibitors and angiotensin 2
receptor antagonists or thiazide
diuretics have the potential to
reduce zinc levels in hypertensive
patients, according to the results of
a study published in the
International Journal of Clinical
Practice.
The research was designed to
explore whether antihypertensive
medicines have the potential to
affect zinc status, and looked at
eight studies which involved the
use of ACE inhibitors, thiazide
diuretics, beta blockers, or ARB
drugs (of which five included a
control group Studies used urinary
zinc excretion, plasma zinc levels or
erythrocyte zinc as key measures of
zinc status).
According to the study’s findings
there were increased urinary zinc
losses for: captopril (from 50 mg/day),
enalapril (20 mg/day), losartan (50
mg/day), losartan (50 mg/day)
together with hydrochlorothiazide
(12.5 mg/day), captopril (75 mg/
day) together with frusemide (40
mg/day) and stand-alone
hydrochlorothiazide (25 mg/day).
The study also noted serum levels
of zinc decreased with captopril
(50–150 mg/day), verapamil (240
mg/day), atenolol (50–150 mg/day)
and the combination of losartan (50mg/
day) and hydrochlorothiazide (12.5
mg/day), eryrthrocyte levels
decreased with use of valsartan (80
mg/day) and in some studies for
captopril, but not for metoprolol
(100 mg/day), atenolol (50–150
mg/day), verapamil (240 mg/day),
doxazosin (4 mg/day) or
amlodipine 10 mg/day).
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